Preclinical Phase III Trials in Translational Stroke Research

Preclinical phase III trials in translational stroke research: call for collective design of framework and guidelines.

O ur understanding of basic stroke pathophysiology, risk factors promoting the disease and its sequelae in the central nervous and peripheral organ systems have progressed tremendously for the past decades. Preclinical research has identified a multitude of potential therapeutic targets to replenish our arsenal for fighting ischemic stroke. 1 Although the efficacy of numerous therapeutic strate...

REPRINT: International, multicenter randomized preclinical trials in translational stroke research: it is time to act.

Stroke-related translational research.

Stroke-related translational research is multifaceted. Herein, we highlight genome-wide association studies and genetic studies of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy, COL4A1 mutations, and cerebral cavernous malformations; advances in molecular biology and biomarkers; newer brain imaging research; and recovery from stroke emphasizing cell-...

The future of clinical research beyond phase III trials.

It is well accepted that prospectively designed, randomized, and appropriately powered clinical trials serve as the gold standard for generating medical evidence in support of the efficacy of a treatment. Successful completion of these socalled phase III trials, however, often can be challenging. Two major issues that often are impediments to implementation and/or completion of phase III trials...

Acute Stroke Imaging Research Roadmap III Imaging Selection and Outcomes in Acute Stroke Reperfusion Clinical Trials

Background and Purpose—The Stroke Imaging Research (STIR) group, the Imaging Working Group of StrokeNet, the American Society of Neuroradiology, and the Foundation of the American Society of Neuroradiology sponsored an imaging session and workshop during the Stroke Treatment Academy Industry Roundtable (STAIR) IX on October 5 to 6, 2015 in Washington, DC. The purpose of this roadmap was to focu...